Smith Drug Store

121 S Grand
Cherokee, OK 73728
Due to COVID-19 requirements and recommendations, many Oklahoma businesses and attractions have made changes to their hours of operation and available services. We encourage all potential visitors to contact the business or attraction directly before visiting for up-to-date information. For Oklahoma State Health Department information and recommendations, visit the COVID-19 resource page.

Smith Drug Store

121 S Grand
Cherokee, OK 73728
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Serving Cherokee-area residents since 1894, Smith Drug Store has quite a heritage of providing medicine, goods and more for the community. For well over a century, the drug store has been a go-to shop, and you’ll discover they offer a delightful variety of home décor, jewelry and other unique items, including baby and women’s clothing. From summer cookout accessories to Eleven Point candles, you're sure to find something for every gift-giving occasion. Smith Drug Store also offers a bridal and baby registry complimented by free gift-wrapping and delivery in Cherokee. 



Sunday: 8:30 am - 6:00 pm
Monday: 8:30 am - 6:00 pm
Tuesday: 8:30 am - 6:00 pm
Wednesday: 8:30 am - 6:00 pm
Thursday: 8:30 am - 6:00 pm
Friday: 8:30 am - 6:00 pm
Saturday: 8:30 am - 1:00 pm
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